Differential gene expression in skin RNA of horses affected with degenerative suspensory ligament desmitis

Degenerative suspensory ligament desmitis as a systemic disorder characterized by proteoglycan accumulation

BACKGROUND Degenerative suspensory ligament desmitis (DSLD) is a debilitating disorder thought to be limited to suspensory ligaments of Peruvian Pasos, Peruvian Paso crosses, Arabians, American Saddlebreds, American Quarter Horses, Thoroughbreds, and some European breeds. It frequently leads to persistent, incurable lameness and need to euthanize affected horses. The pathogenesis remains unclea...

Degenerative Suspensory Ligament Desmitis (DSLD) in Peruvian Paso Horses Is Characterized by Altered Expression of TGFβ Signaling Components in Adipose-Derived Stromal Fibroblasts

Equine degenerative suspensory ligament desmitis (DSLD) in Peruvian Paso horses typically presents at 7-15 years and is characterized by lameness, focal disorganization of collagen fibrils, and chondroid deposition in the body of the ligament. With the aim of developing a test for disease risk (that can be used to screen horses before breeding) we have quantified the expression of 76 TGFβ-signa...

Bilateral degenerative suspensory desmitis with acute rupture in a Standardbred colt

A 3-month-old Standardbred colt was examined for acute, bilateral hindlimb swelling and lameness. Serum chemistry demonstrated elevated muscle enzymes (AST, ALT, LDH and CK). Radiographs of the hindlimbs demonstrated intact proximal sesamoid bones that were displaced distally and subluxation of the pastern joints. Ultrasonography of the affected areas revealed large, diffuse hypoechoic areas in...

In Vivo Evaluation of Extracorporeal Shock Wave Therapy for collagenase Induced Suspensory Ligament Desmitis

Extracorporeal shock wave therapy improved the rate of healing of collagenase-induced suspensory ligament desmitis in horses, as measured by ultrasonographic imaging. Extracorporeal shock wave therapy resulted in a statistically significant decrease in lesion area and improved fiber alignment and echogenicity of the ligament in treated ligaments when compared with control ligaments. Authors’ ad...

Comparison of radiographic changes of the proximal third metacarpal and metatarsal bones in horses with and without proximal suspensory desmitis